The average bus between Manchester Piccadilly Station and 10 Downing Street takes 5h 23m and the fastest bus takes 4h 22m. There is a bus service every few hours from Manchester Piccadilly Station to 10 Downing Street. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Manchester Piccadilly Station and 10 Downing Street. The earliest departure is at 2:45 AM at night, and the last departure from Manchester Piccadilly Station is at 7:30 PM which arrives into 10 Downing Street at 12:06 AM. All services require a transfer at Shudehill Interchange and take an average of 5h 23m. The schedules shown below are for the next available departures.

5h 53m • 1 change

4h 47m • 1 change

4h 55m • 1 change

5h 9m • 1 change

5h 45m • 1 change

4h 56m • 1 change

4h 52m • 1 change

5h 16m • 1 change

6h 2m • 1 change

5h 14m • 1 change

6h 9m • 1 change

5h 15m • 1 change
Want to know about travelling from Manchester Piccadilly Station to 10 Downing Street? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manchester Piccadilly Station to 10 Downing Street. However, there are services departing from Manchester Piccadilly Station station and arriving at 10 Downing Street station via Finchley Road / O2 Centre. The journey, including transfers, takes approximately 5h 23m.
Manchester Piccadilly Station to 10 Downing Street bus services, operated by National Express, depart from Shudehill Interchange station.
Manchester Piccadilly Station to 10 Downing Street bus services, operated by National Express, arrive at Finchley Road / O2 Centre station.
The distance between Manchester Piccadilly Station and 10 Downing Street is 261.6 km. The road distance is 328 km.
FlixBus operates a bus from Shudehill Interchange to Finchley Road / O2 Centre hourly. Tickets cost £23–40 and the journey takes 4h 35m.