The average bus between Manchester Piccadilly Station and London Paddington takes 5h 15m and the fastest bus takes 4h 18m. There is a bus service every few hours from Manchester Piccadilly Station to London Paddington. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Manchester Piccadilly Station and London Paddington. The earliest departure is at 2:45 AM at night, and the last departure from Manchester Piccadilly Station is at 7:30 PM which arrives into London Paddington at 11:53 PM. All services require a transfer at Manchester Central Coach Station and take an average of 5h 15m. The schedules shown below are for the next available departures.

5h 15m • 1 change

4h 55m • 1 change

4h 49m • 1 change

4h 21m • 1 change

5h 38m • 1 change

4h 38m • 1 change

4h 43m • 1 change

5h • 1 change

5h 40m • 1 change

4h 40m • 1 change

4h 45m • 1 change

5h 4m • 1 change

5h 59m • 1 change

5h 5m • 1 change

6h 2m • 1 change

5h 10m • 1 change
Want to know about travelling from Manchester Piccadilly Station to London Paddington? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manchester Piccadilly Station to London Paddington. However, there are services departing from Manchester Piccadilly Station station and arriving at London Paddington station via Marble Arch. The journey, including transfers, takes approximately 5h 15m.
Manchester Piccadilly Station to London Paddington bus services, operated by National Express, depart from Manchester Central Coach Station.
Manchester Piccadilly Station to London Paddington bus services, operated by National Express, arrive at Marble Arch station.
Book your Manchester Piccadilly Station to London Paddington bus tickets online with National Express, London Buses and Go Ahead London.
The distance between Manchester Piccadilly Station and London Paddington is 258.6 km. The road distance is 326 km.
National Express operates a bus from Manchester Central Coach Station to Marble Arch hourly. Tickets cost £35–95 and the journey takes 5h 40m.