The average bus between Manchester Piccadilly Station and Prestwick takes 6h 42m and the fastest bus takes 5h 53m. The bus service runs several times per day from Manchester Piccadilly Station to Prestwick. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Manchester Piccadilly Station and Prestwick. The earliest departure is at 2:10 AM at night, and the last departure from Manchester Piccadilly Station is at 5:20 PM which arrives into Prestwick at 12:10 AM. All services require a transfer at Shudehill Interchange and take an average of 6h 42m. The schedules shown below are for the next available departures.

5h 53m • 1 change

7h • 1 change
Arrives next day

6h 50m • 1 change

6h 30m • 1 change

7h • 1 change
Arrives next day

6h 50m • 1 change

8h 3m • 1 change

7h • 1 change
Arrives next day

6h 50m • 1 change

5h 53m • 1 change

7h • 1 change
Arrives next day

6h 50m • 1 change
Want to know about travelling from Manchester Piccadilly Station to Prestwick? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manchester Piccadilly Station to Prestwick. However, there are services departing from Manchester Piccadilly Station station and arriving at Prestwick station via Buchanan Bus Station station. The journey, including transfers, takes approximately 6h 42m.
Manchester Piccadilly Station to Prestwick bus services, operated by FlixBus, depart from Shudehill Interchange station.
Manchester Piccadilly Station to Prestwick bus services, operated by FlixBus, arrive at Saunterne Road station.
The distance between Manchester Piccadilly Station and Prestwick is 272.2 km. The road distance is 396 km.
You can take a vehicle from Manchester Piccadilly Station to Saunterne Road via Shudehill Interchange and Buchanan Bus Station in around 5h 16m.