The average bus between Manchester Piccadilly Station and Southwark takes 5h 42m and the fastest bus takes 4h 33m. There is a bus service every few hours from Manchester Piccadilly Station to Southwark. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Manchester Piccadilly Station and Southwark. The earliest departure is at 2:45 AM at night, and the last departure from Manchester Piccadilly Station is at 7:30 PM which arrives into Southwark at 12:10 AM. All services require a transfer at Shudehill Interchange and take an average of 5h 42m. The schedules shown below are for the next available departures.

6h 23m • 1 change

5h 31m • 1 change

6h 10m • 1 change

5h 11m • 1 change

6h 23m • 1 change

5h 29m • 1 change

6h 23m • 1 change

6h 10m • 1 change

6h 23m • 1 change

5h 29m • 1 change

6h 23m • 1 change

6h 10m • 1 change
Want to know about travelling from Manchester Piccadilly Station to Southwark? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manchester Piccadilly Station to Southwark. However, there are services departing from Manchester Piccadilly Station station and arriving at Southwark station via Finchley Road / O2 Centre. The journey, including transfers, takes approximately 5h 42m.
Manchester Piccadilly Station to Southwark bus services, operated by National Express, depart from Shudehill Interchange station.
Manchester Piccadilly Station to Southwark bus services, operated by National Express, arrive at Finchley Road / O2 Centre station.
The distance between Manchester Piccadilly Station and Southwark is 262.6 km. The road distance is 328 km.
FlixBus operates a bus from Shudehill Interchange to Finchley Road / O2 Centre hourly. Tickets cost £24–40 and the journey takes 4h 35m.