The average bus between Manchester and London Euston takes 5h 31m and the fastest bus takes 4h 28m. There is a bus service every few hours from Manchester to London Euston. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Manchester and London Euston. The earliest departure is at 2:45 AM at night, and the last departure from Manchester is at 7:30 PM which arrives into London Euston at 11:58 PM. All services require a transfer at Finchley Road / O2 Centre and take an average of 5h 31m. The schedules shown below are for the next available departures.

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6h • 1 changeWant to know about travelling from Manchester to London Euston? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manchester to London Euston. However, there are services departing from Shudehill Interchange station and arriving at Finchley Road / O2 Centre station via Finchley Road / O2 Centre station. The journey, including transfers, takes approximately 5h 31m.
Manchester to London Euston bus services, operated by FlixBus, depart from Shudehill Interchange station.
Manchester to London Euston bus services, operated by FlixBus, arrive at Finchley Road / O2 Centre station.
Book your Manchester to London Euston bus tickets online with Omio.
The distance between Manchester and London Euston is 259.7 km. The road distance is 295 km.
FlixBus operates a bus from Shudehill Interchange to Finchley Road / O2 Centre hourly. Tickets cost £23–35 and the journey takes 4h 35m.