The average bus between Manchester and London Paddington takes 4h 50m and the fastest bus takes 4h 40m. The bus service runs several times per day from Manchester to London Paddington. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Manchester and London Paddington. The earliest departure is at 5:45 AM in the morning, and the last departure from Manchester is at 4:55 PM which arrives into London Paddington at 9:36 PM. All services require a transfer, and take on average 4h 50m. The schedules shown below are for the next available departures.

4h 51m • 1 change
4h 40m • 1 change
4h 51m • 1 change
4h 41m • 1 change
4h 51m • 1 change
4h 40m • 1 change
4h 51m • 1 change
4h 41m • 1 change
4h 46m • 1 change
4h 56m • 1 change
4h 45m • 1 change
5h 21m • 1 changeWant to know about travelling from Manchester to London Paddington? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manchester to London Paddington. However, there are services departing from Manchester station and arriving at London Paddington station via Finchley Road Station station. The journey, including transfers, takes approximately 4h 50m.
Manchester to London Paddington bus services, operated by National Express, depart from Manchester Central Coach Station.
Manchester to London Paddington bus services, operated by National Express, arrive at Finchley Road Station.
Book your Manchester to London Paddington bus tickets online with National Express.
The distance between Manchester and London Paddington is 259.1 km. The road distance is 302 km.
National Express operates a bus from Manchester Central Coach Station to Finchley Road Station every 4 hours. Tickets cost £35–85 and the journey takes 4h 10m.