The average bus between Manchester and Southwark takes 5h 30m and the fastest bus takes 5h 6m. There is a bus service every few hours from Manchester to Southwark. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Manchester and Southwark. The earliest departure is at 2:50 AM at night, and the last departure from Manchester is at 11:59 PM which arrives into Southwark at 6:48 AM. All services require a transfer at Finchley Road / O2 Centre and take an average of 5h 30m. The schedules shown below are for the next available departures.

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5h 10m • 1 changeWant to know about travelling from Manchester to Southwark? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manchester to Southwark. However, there are services departing from Manchester station and arriving at Southwark station via Finchley Road / O2 Centre. The journey, including transfers, takes approximately 5h 30m.
Manchester to Southwark bus services, operated by FlixBus, depart from Shudehill Interchange station.
Manchester to Southwark bus services, operated by FlixBus, arrive at Finchley Road / O2 Centre station.
The distance between Manchester and Southwark is 263.1 km. The road distance is 329 km.
FlixBus operates a bus from Shudehill Interchange to Finchley Road / O2 Centre hourly. Tickets cost £22–35 and the journey takes 4h 35m.