The average bus between Manhattan and Buffalo Depew Station takes 11h 55m and the fastest bus takes 9h 29m. The bus service runs several times per day from Manhattan to Buffalo Depew Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Manhattan and Buffalo Depew Station. The earliest departure is at 5:15 AM in the morning, and the last departure from Manhattan is at 8:00 PM which arrives into Buffalo Depew Station at 6:37 AM. All services require a transfer at Ellicott Street & MTC Static and take an average of 11h 55m. The schedules shown below are for the next available departures.
Arrives next day


17h 10m • 2 changes
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10h 37m • 2 changes


10h 32m • 2 changes


10h 15m • 2 changes
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19h 18m • 2 changes
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14h 1m • 2 changes


10h 3m • 2 changes


11h 37m • 2 changes
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13h 11m • 2 changes


9h 29m • 2 changes


10h 13m • 2 changes
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10h 37m • 2 changes


10h 32m • 2 changes


10h 15m • 2 changes
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17h 10m • 2 changes
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10h 37m • 2 changes
Want to know about travelling from Manhattan to Buffalo Depew Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manhattan to Buffalo Depew Station. However, there are services departing from Manhattan station and arriving at Buffalo Depew Station station via Buffalo. The journey, including transfers, takes approximately 11h 55m.
Manhattan to Buffalo Depew Station bus services, operated by Trailways, depart from New York station.
Manhattan to Buffalo Depew Station bus services, operated by Trailways, arrive at Buffalo station.
The distance between Manhattan and Buffalo Depew Station is 459.5 km. The road distance is 761 km.
Trailways operates a bus from New York to Buffalo every 4 hours. Tickets cost $60–280 and the journey takes 8h. New York Trailways also services this route twice daily.