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Manhattan to Florence buses

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Trip Overview

The average bus between Manhattan and Florence takes 13h 22m and the fastest bus takes 12h 55m. The bus service runs several times per day from Manhattan to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

13h 22m
Duration
686 mi
Distance
$151
Average price
Twice daily
Frequency

Manhattan to Florence bus times

Buses run twice daily between Manhattan and Florence. The earliest departure is at 7:50 PM in the evening, and the last departure from Manhattan is at 11:00 PM which arrives into Florence at 11:55 AM. All services require a transfer, and take on average 13h 22m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

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    Arrives next day

    Greyhound USAGreyhound USA13h 50m • 1 change
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    Arrives next day

    Greyhound USAGreyhound USA12h 55m • 1 change

Departing Sunday, November 8, 2026

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    Arrives next day

    Greyhound USAGreyhound USA13h 50m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA12h 55m • 1 change

Departing Monday, November 9, 2026

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    Arrives next day

    Greyhound USAGreyhound USA13h 50m • 1 change
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    Arrives next day

    Greyhound USAGreyhound USA12h 55m • 1 change

Departing Tuesday, November 10, 2026

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    Arrives next day

    Greyhound USAGreyhound USA13h 50m • 1 change
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    Arrives next day

    Greyhound USAGreyhound USA12h 55m • 1 change

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USA13h 50m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA12h 55m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USA13h 50m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA12h 55m • 1 change

Frequently asked questions

Want to know about travelling from Manhattan to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Manhattan to Florence.ExpandLaunch map view
  • Distance: 685.5 mi
  • Duration: 13h 22m

What companies run services between Manhattan, NY, USA and Florence, SC, USA?

You can take a bus from Port Authority Bus Terminal to Florence Bus Station via Raleigh Bus Station in around 13h 35m.

Operators