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Manhattan to Mechanicsburg buses

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Trip Overview

The average bus between Manhattan and Mechanicsburg takes 6h 15m and the fastest bus takes 4h 55m. The bus service runs several times per day from Manhattan to Mechanicsburg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 15m
Duration
223 mi
Distance
$42
Average price
Twice daily
Frequency

Manhattan to Mechanicsburg bus times

Buses run twice daily between Manhattan and Mechanicsburg. The earliest departure is at 9:55 AM in the morning, and the last departure from Manhattan is at 10:50 PM which arrives into Mechanicsburg at 5:58 AM. All services require a transfer at Harrisburg Bus Station and take an average of 6h 15m. The schedules shown below are for the next available departures.

Departing Friday, October 9, 2026

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    Arrives next day

    Greyhound USARabbit Transit8h 51m • 1 change

Departing Saturday, October 10, 2026

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    Greyhound USARabbit Transit6h 46m • 1 change

Departing Sunday, October 11, 2026

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    Arrives next day

    Greyhound USARabbit Transit7h 8m • 1 change

Departing Monday, October 12, 2026

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    Greyhound USARabbit Transit5h 33m • 1 change
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    Arrives next day

    Greyhound USARabbit Transit7h 8m • 1 change

Departing Tuesday, October 13, 2026

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    Greyhound USARabbit Transit5h 33m • 1 change
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    Arrives next day

    Greyhound USARabbit Transit7h 8m • 1 change

Departing Wednesday, October 14, 2026

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    Greyhound USARabbit Transit5h 33m • 1 change
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    Greyhound USARabbit Transit4h 55m • 1 change
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    Arrives next day

    Greyhound USARabbit Transit7h 8m • 1 change

Departing Thursday, October 15, 2026

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    Greyhound USARabbit Transit5h 33m • 1 change
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    Greyhound USARabbit Transit4h 55m • 1 change
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    Arrives next day

    Greyhound USARabbit Transit7h 8m • 1 change

Departing Friday, October 16, 2026

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    Greyhound USARabbit Transit5h 33m • 1 change
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    Greyhound USARabbit Transit4h 55m • 1 change

Frequently asked questions

Want to know about travelling from Manhattan to Mechanicsburg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Manhattan to Mechanicsburg.ExpandLaunch map view
  • Distance: 222.9 mi
  • Duration: 6h 15m

What companies run services between Manhattan, NY, USA and Mechanicsburg, Cumberland County, PA, USA?

Greyhound USA operates a bus from Port Authority Bus Terminal to Harrisburg Bus Station 5 times a day. Tickets cost $30–55 and the journey takes 3h 35m.

Operators