The average bus between Manhattan and Middletown (Station) takes 6h 28m and the fastest bus takes 5h 31m. The bus service runs several times per day from Manhattan to Middletown (Station). The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Manhattan and Middletown (Station). The earliest departure is at 9:55 AM in the morning, and the last departure from Manhattan is at 10:50 PM which arrives into Middletown (Station) at 5:42 AM. All services require a transfer at Harrisburg Bus Station and take an average of 6h 28m. The schedules shown below are for the next available departures.

5h 38m • 1 change

6h 49m • 1 change
Arrives next day

6h 52m • 1 change

5h 38m • 1 change

6h 49m • 1 change
Arrives next day

6h 52m • 1 change
Want to know about travelling from Manhattan to Middletown (Station)? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manhattan to Middletown (Station). However, there are services departing from Manhattan station and arriving at Middletown (Station) station via Harrisburg Bus Station station. The journey, including transfers, takes approximately 6h 28m.
Manhattan to Middletown (Station) bus services, operated by Greyhound USA, depart from Port Authority Bus Terminal station.
Manhattan to Middletown (Station) bus services, operated by Greyhound USA, arrive at Harrisburg Bus Station.
The distance between Manhattan and Middletown (Station) is 243.2 km. The road distance is 363 km.
Greyhound USA operates a bus from Port Authority Bus Terminal to Harrisburg Bus Station 5 times a day. Tickets cost $30–65 and the journey takes 3h 35m.