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Manhattan to Syracuse, Ny buses

Find Transport to Syracuse, Ny

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Trip Overview

The average bus between Manhattan and Syracuse, Ny takes 5h 13m and the fastest bus takes 4h 45m. The bus service runs several times per day from Manhattan to Syracuse, Ny. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 13m
Duration
260 mi
Distance
$150
Average price
Every 2 hours
Frequency

Manhattan to Syracuse, Ny bus times

Buses run every 2 hours between Manhattan and Syracuse, Ny. The earliest departure is at 1:25 AM at night, and the last departure from Manhattan is at 10:50 PM which arrives into Syracuse, Ny at 3:55 AM. All services run direct with no transfers required, and take on average 5h 13m. The schedules shown below are for the next available departures.

Departing Friday, November 6, 2026

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    bus bus 5h 40m • Direct
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    bus bus 5h 15m • Direct
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    bus bus 5h 20m • Direct
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    bus bus 5h 15m • Direct
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Departing Saturday, November 7, 2026

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    bus bus 4h 45m • Direct
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    bus bus 5h 10m • Direct
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    bus bus 5h 35m • Direct
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    bus bus 5h 40m • Direct
  • Show more

Departing Sunday, November 8, 2026

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    bus bus 4h 45m • Direct
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    bus bus 5h 10m • Direct
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    bus bus 5h 35m • Direct
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    bus bus 5h 40m • Direct
  • Show more

Departing Monday, November 9, 2026

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    bus bus 4h 45m • Direct
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    bus bus 5h 10m • Direct
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    bus bus 5h 35m • Direct
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    bus bus 5h 40m • Direct
  • Show more

Departing Tuesday, November 10, 2026

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    bus bus 4h 45m • Direct
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    bus bus 5h 10m • Direct
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    bus bus 5h 40m • Direct
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    bus bus 5h 20m • Direct
  • Show more

Departing Wednesday, November 11, 2026

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    bus bus 4h 45m • Direct
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    bus bus 5h 10m • Direct
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    bus bus 5h 40m • Direct
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    bus bus 5h 15m • Direct
  • Show more

Departing Thursday, November 12, 2026

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    bus bus 4h 45m • Direct
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    bus bus 5h 10m • Direct
  •  → 

    bus bus 5h 35m • Direct
  •  → 

    bus bus 5h 40m • Direct
  • Show more

Frequently asked questions

Want to know about travelling from Manhattan to Syracuse, Ny? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Manhattan to Syracuse, Ny.ExpandLaunch map view
  • Distance: 260.5 mi
  • Duration: 5h 13m

What companies run services between Manhattan, NY, USA and Syracuse, Ny, NY, USA?

Greyhound USA operates a bus from Port Authority Bus Terminal to Syracuse Bus Station every 2 hours. Tickets cost $45–75 and the journey takes 4h 45m. Two other operators also service this route.

Operators