The average bus between Mannheim and Saint-Louis takes 4h 25m and the fastest bus takes 4h 13m. The bus service runs several times per day from Mannheim to Saint-Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Mannheim and Saint-Louis. The earliest departure is at 6:30 AM in the morning, and the last departure from Mannheim is at 9:59 PM which arrives into Saint-Louis at 4:22 AM. All services require a transfer at Basel SBB and take an average of 4h 25m. The schedules shown below are for the next available departures.

6h 14m • 1 change

6h 39m • 1 change
Arrives next day

6h 23m • 1 change

6h 14m • 1 change

6h 39m • 1 change
Arrives next day

6h 23m • 1 change

6h 14m • 1 change

6h 39m • 1 change
Arrives next day

6h 23m • 1 change

6h 14m • 1 change

6h 39m • 1 change
Arrives next day

6h 23m • 1 change
Want to know about travelling from Mannheim to Saint-Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mannheim to Saint-Louis. However, there are services departing from Mannheim station and arriving at Saint-Louis station via Basel SBB. The journey, including transfers, takes approximately 4h 25m.
Mannheim to Saint-Louis bus services, operated by FlixBus, depart from Mannheim central bus station.
Mannheim to Saint-Louis bus services, operated by FlixBus, arrive at Basel SBB station.
Book your Mannheim to Saint-Louis bus tickets online with FlixBus and Basler Verkehrs-Betriebe.
The distance between Mannheim and Saint-Louis is 221.3 km. The road distance is 273 km.
FlixBus operates a bus from Mannheim central bus station to Basel SBB 5 times a day. Tickets cost €22–40 and the journey takes 3h 35m.