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Mayo Clinic to Chicago buses

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Trip Overview

The bus between Mayo Clinic and Chicago takes 8h 45m. The bus runs, on average, 2 times per week from Mayo Clinic to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

8h 45m
Duration
358 mi
Distance
$120
Average price
Twice a week
Frequency

Mayo Clinic to Chicago bus times

Buses run twice a week between Mayo Clinic and Chicago. The service departs Mayo Clinic at 12:35 PM in the afternoon, which arrives into Chicago at 20:20:00. All services require a transfer at Rochester and take an average of 8h 45m. The schedules shown below are for the next available departures.

Departing Saturday, October 31, 2026

  •  → 

    Jefferson LinesRockland Coaches8h 45m • 1 change

Departing Sunday, November 1, 2026

  •  → 

    Jefferson LinesRockland Coaches8h 45m • 1 change

Frequently asked questions

Want to know about travelling from Mayo Clinic to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mayo Clinic to Chicago.ExpandLaunch map view
  • Distance: 357.9 mi
  • Duration: 8h 45m

What companies run services between Mayo Clinic, MN, USA and Chicago, IL, USA?

You can take a vehicle from Mayo Clinic to W Jackson Blvd, after S Clinton St via Rochester, Madison, and 250 N. Lake St - Madison UW Campus in around 8h 59m.

Operators