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Mayo Clinic to Cleveland buses

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Trip Overview

The average bus between Mayo Clinic and Cleveland takes 28h 35m and the fastest bus takes 28h 25m. The bus runs, on average, 6 times per week from Mayo Clinic to Cleveland. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

28h 35m
Duration
717 mi
Distance
$168
Average price
6 times a week
Frequency

Mayo Clinic to Cleveland bus times

Buses run 6 times a week between Mayo Clinic and Cleveland. The service departs Mayo Clinic at 12:35 PM in the afternoon, which arrives into Cleveland at 17:00:00. All services require a transfer at Rochester and take an average of 28h 35m. The schedules shown below are for the next available departures.

Departing Friday, October 30, 2026

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    Arrives next day

    Jefferson LinesGreyhound USABarons Bus28h 25m • 2 changes

Departing Saturday, October 31, 2026

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    Arrives next day

    Jefferson LinesGreyhound USABarons Bus29h 25m • 2 changes

Departing Sunday, November 1, 2026

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    Arrives next day

    Jefferson LinesGreyhound USABarons Bus28h 25m • 2 changes

Departing Monday, November 2, 2026

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    Arrives next day

    Jefferson LinesGreyhound USABarons Bus28h 25m • 2 changes

Departing Tuesday, November 3, 2026

  •  → 

    Arrives next day

    Jefferson LinesGreyhound USABarons Bus28h 25m • 2 changes

Departing Wednesday, November 4, 2026

  •  → 

    Arrives next day

    Jefferson LinesGreyhound USABarons Bus28h 25m • 2 changes

Frequently asked questions

Want to know about travelling from Mayo Clinic to Cleveland? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mayo Clinic to Cleveland.ExpandLaunch map view
  • Distance: 717.4 mi
  • Duration: 28h 35m

What companies run services between Mayo Clinic, MN, USA and Cleveland, OH, USA?

You can take a vehicle from Mayo Clinic to Cleveland via Rochester, Milwaukee, Milwaukee Intermodal Station, and Chicago in around 16h 23m.

Operators