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Mayo Clinic to Cleveland Clinic buses

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Trip Overview

The average bus between Mayo Clinic and Cleveland Clinic takes 29h and the fastest bus takes 28h 48m. The bus runs, on average, 6 times per week from Mayo Clinic to Cleveland Clinic. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

29h
Duration
722 mi
Distance
$171
Average price
6 times a week
Frequency

Mayo Clinic to Cleveland Clinic bus times

Buses run 6 times a week between Mayo Clinic and Cleveland Clinic. The service departs Mayo Clinic at 12:35 PM in the afternoon, which arrives into Cleveland Clinic at 17:38:00. All services require a transfer at Rochester and take an average of 29h. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Jefferson LinesGreyhound USABarons BusGreater Cleveland Transit29h 3m • 3 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Jefferson LinesGreyhound USABarons BusGreater Cleveland Transit28h 48m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Jefferson LinesGreyhound USABarons BusGreater Cleveland Transit29h • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Jefferson LinesGreyhound USABarons BusGreater Cleveland Transit29h 3m • 3 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Jefferson LinesGreyhound USABarons BusGreater Cleveland Transit29h 3m • 3 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    Jefferson LinesGreyhound USABarons BusGreater Cleveland Transit29h 3m • 3 changes

Frequently asked questions

Want to know about travelling from Mayo Clinic to Cleveland Clinic? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mayo Clinic to Cleveland Clinic.ExpandLaunch map view
  • Distance: 722.4 mi
  • Duration: 29h

What companies run services between Mayo Clinic, MN, USA and Cleveland Clinic, OH, USA?

You can take a vehicle from Mayo Clinic to Cleveland Clinic via Rochester, Milwaukee, Milwaukee Intermodal Station, Chicago, Cleveland, Superior Av & E 13Th St, and E 105Th St & Chester Av in around 17h 7m.

Operators