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Mayo Clinic to Detroit buses

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Trip Overview

The average bus between Mayo Clinic and Detroit takes 32h and the fastest bus takes 31h 40m. The bus runs, on average, 3 times per week from Mayo Clinic to Detroit. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

32h
Duration
652 mi
Distance
$154
Average price
3 times a week
Frequency

Mayo Clinic to Detroit bus times

Buses run 3 times a week between Mayo Clinic and Detroit. The service departs Mayo Clinic at 12:35 PM in the afternoon, which arrives into Detroit at 20:15:00. All services require a transfer at Rochester and take an average of 32h. The schedules shown below are for the next available departures.

Departing Friday, October 30, 2026

  •  → 

    Arrives next day

    Jefferson LinesFlixbus USA31h 40m • 1 change

Departing Saturday, October 31, 2026

  •  → 

    Arrives next day

    Jefferson LinesFlixbus USA32h 40m • 1 change

Departing Sunday, November 1, 2026

  •  → 

    Arrives next day

    Jefferson LinesFlixbus USA31h 40m • 1 change

Frequently asked questions

Want to know about travelling from Mayo Clinic to Detroit? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mayo Clinic to Detroit.ExpandLaunch map view
  • Distance: 651.5 mi
  • Duration: 32h

What companies run services between Mayo Clinic, MN, USA and Detroit, MI, USA?

You can take a vehicle from Mayo Clinic to Detroit Bus Station via Rochester, Milwaukee, and Milwaukee Intermodal Station in around 14h 18m.

Operators