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Mayo Clinic to Niagara Falls buses

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Trip Overview

The average bus between Mayo Clinic and Niagara Falls takes 36h 9m and the fastest bus takes 35h 59m. The bus runs, on average, 6 times per week from Mayo Clinic to Niagara Falls. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

36h 9m
Duration
932 mi
Distance
$205
Average price
6 times a week
Frequency

Mayo Clinic to Niagara Falls bus times

Buses run 6 times a week between Mayo Clinic and Niagara Falls. The service departs Mayo Clinic at 12:35 PM in the afternoon, which arrives into Niagara Falls at 00:34:35. All services require a transfer at Rochester and take an average of 36h 9m. The schedules shown below are for the next available departures.

Departing Monday, October 26, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USABarons BusBarons BusNFTA35h 59m • 4 changes

Departing Tuesday, October 27, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USABarons BusBarons BusNFTA35h 59m • 4 changes

Departing Wednesday, October 28, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USABarons BusBarons BusNFTA35h 59m • 4 changes

Departing Thursday, October 29, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USABarons BusBarons BusNFTA35h 59m • 4 changes

Departing Friday, October 30, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USABarons BusBarons BusNFTA36h • 4 changes

Departing Saturday, October 31, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USABarons BusBarons BusNFTA36h 58m • 4 changes

Frequently asked questions

Want to know about travelling from Mayo Clinic to Niagara Falls? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mayo Clinic to Niagara Falls.ExpandLaunch map view
  • Distance: 931.6 mi
  • Duration: 36h 9m

What companies run services between Mayo Clinic, MN, USA and Niagara Falls, NY, USA?

You can take a vehicle from Mayo Clinic to Main Street & Pine Avenue via Rochester, Milwaukee, Milwaukee Intermodal Station, Chicago, Cleveland, and Ellicott Street & MTC Static in around 21h 56m.

Operators