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Mayo Clinic to Niagara Falls buses

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Trip Overview

The average bus between Mayo Clinic and Niagara Falls takes 35h 59m and the fastest bus takes 35h 58m. The bus runs, on average, 6 times per week from Mayo Clinic to Niagara Falls. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

35h 59m
Duration
932 mi
Distance
$205
Average price
6 times a week
Frequency

Mayo Clinic to Niagara Falls bus times

Buses run 6 times a week between Mayo Clinic and Niagara Falls. The service departs Mayo Clinic at 12:35 PM in the afternoon, which arrives into Niagara Falls at 00:34:35. All services require a transfer at Rochester and take an average of 35h 59m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USABarons BusBarons BusNFTA35h 59m • 4 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USABarons BusBarons BusNFTA36h • 4 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USABarons BusBarons BusNFTA35h 58m • 4 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USABarons BusBarons BusNFTA35h 59m • 4 changes

Departing Monday, November 9, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USABarons BusBarons BusNFTA35h 59m • 4 changes

Departing Tuesday, November 10, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USABarons BusBarons BusNFTA35h 59m • 4 changes

Frequently asked questions

Want to know about travelling from Mayo Clinic to Niagara Falls? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mayo Clinic to Niagara Falls.ExpandLaunch map view
  • Distance: 931.5 mi
  • Duration: 35h 59m

What companies run services between Mayo Clinic, MN, USA and Niagara Falls, NY, USA?

You can take a vehicle from Mayo Clinic to Main Street & Pine Avenue via Rochester, Milwaukee, Milwaukee Intermodal Station, Chicago, Cleveland, and Ellicott Street & MTC Static in around 21h 55m.

Operators