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Mayo Clinic to Pennsylvania buses

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Trip Overview

The bus between Mayo Clinic and Pennsylvania takes 39h 35m. The bus runs, on average, 3 times per week from Mayo Clinic to Pennsylvania. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

39h 35m
Duration
1,289 mi
Distance
$283
Average price
3 times a week
Frequency

Mayo Clinic to Pennsylvania bus times

Buses run 3 times a week between Mayo Clinic and Pennsylvania. The service departs Mayo Clinic at 12:35 PM in the afternoon, which arrives into Pennsylvania at 04:10:00. All services require a transfer at Rochester and take an average of 39h 35m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USAFlixbus USA39h 35m • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USAFlixbus USA39h 35m • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USAFlixbus USA39h 35m • 2 changes

Frequently asked questions

Want to know about travelling from Mayo Clinic to Pennsylvania? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mayo Clinic to Pennsylvania.ExpandLaunch map view
  • Distance: 1,288.8 mi
  • Duration: 39h 35m

What companies run services between Mayo Clinic, MN, USA and Pennsylvania, USA?

You can take a vehicle from Mayo Clinic to Philadelphia Bus Station via Rochester, Milwaukee, Milwaukee Intermodal Station, and Chicago Bus Station in around 29h 36m.

Operators