Rome2Rio

Mayo Clinic to Springfield buses

Find Transport to Springfield

View schedule
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

Trip Overview

The average bus between Mayo Clinic and Springfield takes 2d 2h and the fastest bus takes 46h 40m. The bus runs, on average, 5 times per week from Mayo Clinic to Springfield. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 2h
Duration
1,498 mi
Distance
$320
Average price
5 times a week
Frequency

Mayo Clinic to Springfield bus times

Buses run 5 times a week between Mayo Clinic and Springfield. The service departs Mayo Clinic at 12:35 PM in the afternoon, which arrives into Springfield at 11:15:00. All services require a transfer at Rochester and take an average of 2d 2h. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesFlixbus USAFlixbus USAFlixbus USA46h 40m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesFlixbus USAFlixbus USAFlixbus USA46h 40m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesFlixbus USAFlixbus USAFlixbus USA46h 40m • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +3 days

    Jefferson LinesFlixbus USAFlixbus USAFlixbus USA2d 17h • 3 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesFlixbus USAFlixbus USAFlixbus USA46h 40m • 3 changes

Frequently asked questions

Want to know about travelling from Mayo Clinic to Springfield? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mayo Clinic to Springfield.ExpandLaunch map view
  • Distance: 1,497.9 mi
  • Duration: 2d 2h

What companies run services between Mayo Clinic, MN, USA and Springfield, MA, USA?

You can take a vehicle from Mayo Clinic to Springfield Union Station via Rochester, Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, and New York Midtown in around 33h 11m.

Operators