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Mayo Clinic to Springfield buses

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Trip Overview

The bus between Mayo Clinic and Springfield takes 21h 55m. The bus runs, on average, 3 times per week from Mayo Clinic to Springfield. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

21h 55m
Duration
683 mi
Distance
$209
Average price
3 times a week
Frequency

Mayo Clinic to Springfield bus times

Buses run 3 times a week between Mayo Clinic and Springfield. The service departs Mayo Clinic at 2:45 PM in the afternoon, which arrives into Springfield at 12:40:00. All services require a transfer at Rochester and take an average of 21h 55m. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

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    Arrives next day

    Jefferson LinesJefferson LinesJefferson Lines21h 55m • 2 changes

Departing Tuesday, November 10, 2026

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    Arrives next day

    Jefferson LinesJefferson LinesJefferson Lines21h 55m • 2 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    Jefferson LinesJefferson LinesJefferson Lines21h 55m • 2 changes

Frequently asked questions

Want to know about travelling from Mayo Clinic to Springfield? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mayo Clinic to Springfield.ExpandLaunch map view
  • Distance: 683.5 mi
  • Duration: 21h 55m

What companies run services between Mayo Clinic, MN, USA and Springfield, MO, USA?

You can take a vehicle from Mayo Clinic to Springfield via Rochester, Saint Paul Union Depot, Kansas City Bus Station, and Kansas City in around 15h 21m.

Operators