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Mayo Clinic to Toronto buses

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Trip Overview

The average bus between Mayo Clinic and Toronto takes 42h and the fastest bus takes 41h 40m. The bus runs, on average, 3 times per week from Mayo Clinic to Toronto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

42h
Duration
1,448 km
Distance
$282
Average price
3 times a week
Frequency

Mayo Clinic to Toronto bus times

Buses run 3 times a week between Mayo Clinic and Toronto. The service departs Mayo Clinic at 12:35 PM in the afternoon, which arrives into Toronto at 05:15:00. All services require a transfer at Rochester and take an average of 42h. The schedules shown below are for the next available departures.

Departing Friday, October 30, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesFlixbus USAFlixbus USA41h 40m • 2 changes

Departing Saturday, October 31, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesFlixbus USAFlixbus USA42h 40m • 2 changes

Departing Sunday, November 1, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesFlixbus USAFlixbus USA41h 40m • 2 changes

Frequently asked questions

Want to know about travelling from Mayo Clinic to Toronto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mayo Clinic to Toronto.ExpandLaunch map view
  • Distance: 1,447.9 km
  • Duration: 42h

What companies run services between Mayo Clinic, MN, USA and Toronto, ON, Canada?

You can take a vehicle from Mayo Clinic to Toronto via Rochester, Milwaukee, Milwaukee Intermodal Station, and Detroit Bus Station in around 21h 43m.

Operators