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Mechanicsburg to Buffalo buses

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Trip Overview

The average bus between Mechanicsburg and Buffalo takes 16h 1m and the fastest bus takes 12h 1m. There is at least one bus per day from Mechanicsburg to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

16h 1m
Duration
401 mi
Distance
$132
Average price
Once daily
Frequency

Mechanicsburg to Buffalo bus times

Buses run once daily between Mechanicsburg and Buffalo. The earliest departure is at 8:48 AM in the morning, and the last departure from Mechanicsburg is at 4:48 PM which arrives into Buffalo at 10:50 PM. All services require a transfer at Market Square Transfer Center and take an average of 16h 1m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

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    Rabbit TransitTrailwaysGreyhound USA14h 1m • 2 changes

Departing Friday, November 6, 2026

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    Rabbit TransitTrailwaysGreyhound USA14h 1m • 2 changes

Departing Saturday, November 7, 2026

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    Rabbit TransitTrailwaysGreyhound USA12h 1m • 2 changes
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    Arrives next day

    Rabbit TransitTrailwaysGreyhound USA30h 1m • 2 changes

Departing Monday, November 9, 2026

  •  → 

    Rabbit TransitTrailwaysGreyhound USA14h 1m • 2 changes

Departing Tuesday, November 10, 2026

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    Rabbit TransitTrailwaysGreyhound USA14h 1m • 2 changes

Departing Wednesday, November 11, 2026

  •  → 

    Rabbit TransitTrailwaysGreyhound USA14h 1m • 2 changes

Frequently asked questions

Want to know about travelling from Mechanicsburg to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mechanicsburg to Buffalo.ExpandLaunch map view
  • Distance: 400.8 mi
  • Duration: 16h 1m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and Buffalo, NY, USA?

You can take a bus from E Main St & Arch St EB to Buffalo via Market Square Transfer Center, Harrisburg, Pa, and Scranton Bus Station in around 11h 27m.

Operators