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Mechanicsburg to Myrtle Beach buses

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Trip Overview

The average bus between Mechanicsburg and Myrtle Beach takes 31h 26m and the fastest bus takes 24h 46m. The bus runs, on average, 3 times per week from Mechanicsburg to Myrtle Beach. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

31h 26m
Duration
600 mi
Distance
$132
Average price
3 times a week
Frequency

Mechanicsburg to Myrtle Beach bus times

Buses run 3 times a week between Mechanicsburg and Myrtle Beach. The earliest departure is at 8:48 AM in the morning, and the last departure from Mechanicsburg is at 4:48 PM which arrives into Myrtle Beach at 11:35 AM. All services require a transfer at Market Square Transfer Center and take an average of 31h 26m. The schedules shown below are for the next available departures.

Departing Friday, November 6, 2026

  •  → 

    Arrives next day

    Rabbit TransitGreyhound USAGreyhound USAGreyhound USA26h 46m • 3 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives next day

    Rabbit TransitGreyhound USAGreyhound USAGreyhound USA24h 46m • 3 changes
  •  → 

    Arrives +2 days

    Rabbit TransitGreyhound USAGreyhound USAGreyhound USA42h 46m • 3 changes

Frequently asked questions

Want to know about travelling from Mechanicsburg to Myrtle Beach? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mechanicsburg to Myrtle Beach.ExpandLaunch map view
  • Distance: 599.8 mi
  • Duration: 31h 26m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and Myrtle Beach, SC, USA?

You can take a bus from E Main St & Arch St EB to Myrtle Beach Bus Station via Market Square Transfer Center, Harrisburg Bus Station, Washington Union Station, and Raleigh Bus Station in around 15h.

Operators