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Mechanicsburg to Niagara Falls buses

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Trip Overview

The average bus between Mechanicsburg and Niagara Falls takes 17h 46m and the fastest bus takes 13h 47m. There is at least one bus per day from Mechanicsburg to Niagara Falls. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

17h 46m
Duration
426 mi
Distance
$134
Average price
Once daily
Frequency

Mechanicsburg to Niagara Falls bus times

Buses run once daily between Mechanicsburg and Niagara Falls. The earliest departure is at 8:48 AM in the morning, and the last departure from Mechanicsburg is at 4:48 PM which arrives into Niagara Falls at 12:33 AM. All services require a transfer at Market Square Transfer Center and take an average of 17h 46m. The schedules shown below are for the next available departures.

Departing Monday, November 2, 2026

  •  → 

    Arrives next day

    Rabbit TransitTrailwaysGreyhound USANFTA15h 46m • 3 changes

Departing Tuesday, November 3, 2026

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    Arrives next day

    Rabbit TransitTrailwaysGreyhound USANFTA15h 46m • 3 changes

Departing Wednesday, November 4, 2026

  •  → 

    Arrives next day

    Rabbit TransitTrailwaysGreyhound USANFTA15h 46m • 3 changes

Departing Thursday, November 5, 2026

  •  → 

    Arrives next day

    Rabbit TransitTrailwaysGreyhound USANFTA15h 46m • 3 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives next day

    Rabbit TransitTrailwaysGreyhound USANFTA15h 46m • 3 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives next day

    Rabbit TransitTrailwaysGreyhound USANFTA13h 47m • 3 changes
  •  → 

    Arrives +2 days

    Rabbit TransitTrailwaysGreyhound USANFTA31h 45m • 3 changes

Frequently asked questions

Want to know about travelling from Mechanicsburg to Niagara Falls? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mechanicsburg to Niagara Falls.ExpandLaunch map view
  • Distance: 425.7 mi
  • Duration: 17h 46m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and Niagara Falls, NY, USA?

You can take a bus from E Main St & Arch St EB to Main Street & Pine Avenue via Market Square Transfer Center, Harrisburg, Pa, Scranton Bus Station, Buffalo, and Ellicott Street & MTC Static in around 12h 50m.

Operators