The average bus between Mechanicsburg and Pittsburgh takes 5h 31m and the fastest bus takes 5h 6m. The bus service runs several times per day from Mechanicsburg to Pittsburgh. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Mechanicsburg and Pittsburgh. The earliest departure is at 12:18 PM in the afternoon, and the last departure from Mechanicsburg is at 7:18 PM which arrives into Pittsburgh at 12:25 AM. All services require a transfer at Market Square Transfer Center and take an average of 5h 31m. The schedules shown below are for the next available departures.

6h 1m • 1 change

5h 11m • 1 change
Arrives next day

5h 6m • 1 change

6h 1m • 1 change

5h 11m • 1 change
Arrives next day

5h 6m • 1 change

6h 1m • 1 change

5h 11m • 1 change
Arrives next day

5h 6m • 1 change
Want to know about travelling from Mechanicsburg to Pittsburgh? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mechanicsburg to Pittsburgh. However, there are services departing from Mechanicsburg station and arriving at Pittsburgh station via Pittsburgh Intermodal Station station. The journey, including transfers, takes approximately 5h 31m.
Mechanicsburg to Pittsburgh bus services, operated by Rabbit Transit, depart from Harrisburg Bus Station.
Mechanicsburg to Pittsburgh bus services, operated by Rabbit Transit, arrive at Pittsburgh Intermodal Station.
The distance between Mechanicsburg and Pittsburgh is 254.8 km. The road distance is 335 km.
Greyhound USA operates a bus from Harrisburg Bus Station to Pittsburgh Intermodal Station every 4 hours. Tickets cost $30–65 and the journey takes 3h 45m. Flixbus USA also services this route twice daily.