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Mechanicsburg to St. Louis buses

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Trip Overview

The average bus between Mechanicsburg and St. Louis takes 20h 48m and the fastest bus takes 19h 56m. The bus service runs several times per day from Mechanicsburg to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

20h 48m
Duration
812 mi
Distance
$212
Average price
Twice daily
Frequency

Bus

best
  1. Take the bus from Harrisburg Bus Station to St Louis Bus Stationbus bus Greyhound US0421
19h 36m
$171–252

Mechanicsburg to St. Louis bus times

Buses run twice daily between Mechanicsburg and St. Louis. The earliest departure is at 12:19 PM in the afternoon, and the last departure from Mechanicsburg is at 7:19 PM which arrives into St. Louis at 3:10 PM. All services require a transfer at Market Square Transfer Center and take an average of 20h 48m. The schedules shown below are for the next available departures.

Frequently asked questions

Want to know about travelling from Mechanicsburg to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mechanicsburg to St. Louis.ExpandLaunch map view
  • Distance: 812 mi
  • Duration: 20h 48m

What companies run services between Mechanicsburg, Cumberland County, PA, USA and St. Louis, MO, USA?

Greyhound USA operates a bus from Harrisburg Bus Station to St Louis Bus Station twice daily. Tickets cost $130–250 and the journey takes 18h 5m. Jefferson Lines also services this route twice daily.

Operators