The average bus between Melrose Park and Indianapolis takes 5h 51m and the fastest bus takes 4h 56m. The bus service runs several times per day from Melrose Park to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Melrose Park and Indianapolis. The earliest departure is at 5:17 AM in the morning, and the last departure from Melrose Park is at 11:05 PM which arrives into Indianapolis at 11:50 AM. All services require a transfer at Forest Park CTA Station and take an average of 5h 51m. The schedules shown below are for the next available departures.



6h 33m • 3 changes



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6h 44m • 3 changes



6h 29m • 3 changes



6h 39m • 3 changes



7h 24m • 3 changes



5h 56m • 3 changes



6h 36m • 3 changes



7h 21m • 3 changes



7h 11m • 3 changes



6h 33m • 3 changes



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6h 4m • 3 changes
Want to know about travelling from Melrose Park to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Melrose Park to Indianapolis. However, there are services departing from Melrose Park station and arriving at Indianapolis station via Indianapolis Union Station station. The journey, including transfers, takes approximately 5h 51m.
Melrose Park to Indianapolis bus services, operated by Pace Bus, depart from Chicago Bus Station.
Melrose Park to Indianapolis bus services, operated by Pace Bus, arrive at Indianapolis Union Station.
The distance between Melrose Park and Indianapolis is 276.8 km. The road distance is 310 km.
Jefferson Lines operates a bus from Chicago Bus Station to Indianapolis Union Station 5 times a day. Tickets cost $50–70 and the journey takes 3h 5m. Greyhound USA also services this route 5 times a day.