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Melrose Park to Indianapolis buses

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Trip Overview

The average bus between Melrose Park and Indianapolis takes 5h 55m and the fastest bus takes 4h 56m. The bus service runs several times per day from Melrose Park to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 55m
Duration
194 mi
Distance
$45
Average price
Every 4 hours
Frequency

Bus via Kedzie-Homan (Greyhound)

best
  1. Take the bus from Chicago Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
5h 29m
$35–55

Melrose Park to Indianapolis bus times

Buses run every 4 hours between Melrose Park and Indianapolis. The earliest departure is at 5:17 AM in the morning, and the last departure from Melrose Park is at 11:05 PM which arrives into Indianapolis at 11:50 AM. All services require a transfer at Forest Park CTA Station - Bus Stop A and take an average of 5h 55m. The schedules shown below are for the next available departures.

Departing Thursday, October 8, 2026

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 4m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA6h 19m • 3 changes

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    Arrives next day

    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 38m • 3 changes

Departing Friday, October 9, 2026

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 33m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 13m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 13m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 4m • 3 changes
  • Show more

Departing Saturday, October 10, 2026

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 44m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 29m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 39m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA6h 24m • 3 changes
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Departing Sunday, October 11, 2026

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA4h 56m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 36m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA6h 21m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA6h 11m • 3 changes
  • Show more

Departing Monday, October 12, 2026

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 33m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 13m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 13m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 4m • 3 changes
  • Show more

Departing Tuesday, October 13, 2026

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 33m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 13m • 3 changes

  •  → 

    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 13m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 4m • 3 changes
  • Show more

Departing Wednesday, October 14, 2026

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA5h 13m • 3 changes

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    Pace BusPace BusChicago Transit (CTA)Flixbus USA6h 19m • 3 changes

Frequently asked questions

Want to know about travelling from Melrose Park to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Melrose Park to Indianapolis.ExpandLaunch map view
  • Distance: 194 mi
  • Duration: 5h 55m

What companies run services between Melrose Park, IL, USA and Indianapolis, IN, USA?

Greyhound USA operates a bus from Chicago Bus Station to Indianapolis Union Station 5 times a day. Tickets cost $28–45 and the journey takes 3h 5m.

Operators