The average bus between Mesa and Palm Desert takes 9h 25m and the fastest bus takes 7h 31m. The bus service runs several times per day from Mesa to Palm Desert. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Mesa and Palm Desert. The earliest departure is at 5:02 AM in the morning, and the last departure from Mesa is at 10:29 PM which arrives into Palm Desert at 1:19 PM. All services require a transfer at Downtown Phx Hub/Washington St and take an average of 9h 25m. The schedules shown below are for the next available departures.



8h 17m • 3 changes
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10h 12m • 3 changes
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9h 11m • 3 changes



8h 17m • 3 changes
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10h 12m • 3 changes
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9h 11m • 3 changes



8h 17m • 3 changes
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10h 12m • 3 changes
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9h 11m • 3 changes



7h 52m • 3 changes



7h 31m • 3 changes



9h 22m • 3 changes
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10h 19m • 3 changes



7h 38m • 3 changes



10h 1m • 3 changes
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10h 30m • 3 changes
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9h 57m • 3 changes
Want to know about travelling from Mesa to Palm Desert? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mesa to Palm Desert. However, there are services departing from Mesa station and arriving at Palm Desert station via Indio Bus Station station. The journey, including transfers, takes approximately 9h 25m.
Mesa to Palm Desert bus services, operated by Valley Metro, depart from 2707 W McDowell Rd - Phoenix station.
Mesa to Palm Desert bus services, operated by Valley Metro, arrive at Indio Bus Station.
The distance between Mesa and Palm Desert is 423.2 km. The road distance is 439 km.
Omnibus Express operates a bus from 2707 W McDowell Rd - Phoenix to Indio Bus Station once daily. Tickets cost $60–80 and the journey takes 3h 30m.