Rome2Rio

Mesa to Santa Ana buses

Find Transport to Santa Ana

View schedule

Trip Overview

The average bus between Mesa and Santa Ana takes 9h 9m and the fastest bus takes 8h 39m. The bus runs, on average, 2 times per week from Mesa to Santa Ana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

9h 9m
Duration
428 mi
Distance
$59
Average price
Twice a week
Frequency

Mesa to Santa Ana bus times

Buses run twice a week between Mesa and Santa Ana. The service departs Mesa at 6:31 AM in the morning, which arrives into Santa Ana at 15:10:00. All services require a transfer at Sycamore/Main St TC and take an average of 9h 9m. The schedules shown below are for the next available departures.

Departing Friday, October 30, 2026

  •  → 

    Valley MetroValley MetroHoang ExpressOCTA8h 39m • 3 changes

Departing Monday, November 2, 2026

  •  → 

    Valley MetroValley MetroHoang ExpressOCTA9h 39m • 3 changes

Frequently asked questions

Want to know about travelling from Mesa to Santa Ana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mesa to Santa Ana.ExpandLaunch map view
  • Distance: 427.8 mi
  • Duration: 9h 9m

What companies run services between Mesa, AZ, USA and Santa Ana, CA, USA?

Hoang Express operates a bus from Chandler, AZ - 1901 W Warner Rd to Westminster, CA - ABC Supermarket twice a week. Tickets cost $45–60 and the journey takes 7h 30m. Xe Do Hoang Transportation also services this route twice a week.

Operators