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Mesa to Santa Clarita buses

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Trip Overview

The average bus between Mesa and Santa Clarita takes 16h 19m and the fastest bus takes 10h 36m. The bus service runs several times per day from Mesa to Santa Clarita. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

16h 19m
Duration
433 mi
Distance
Twice daily
Frequency

Mesa to Santa Clarita bus times

Buses run twice daily between Mesa and Santa Clarita. The earliest departure is at 5:02 AM in the morning, and the last departure from Mesa is at 9:04 PM which arrives into Santa Clarita at 6:40 AM. All services require a transfer at 24th St/Baseline PNR and take an average of 16h 19m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

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    Arrives next day

    Valley MetroValley MetroGreyhound USAAmtrak15h 49m • 3 changes
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    Arrives next day

    Valley MetroValley MetroGreyhound USAAmtrak11h 14m • 3 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    Valley MetroValley MetroGreyhound USAAmtrak16h 29m • 3 changes
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    Arrives next day

    Valley MetroValley MetroGreyhound USAAmtrak11h 22m • 3 changes

Departing Monday, November 9, 2026

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    Arrives next day

    Valley MetroValley MetroGreyhound USAAmtrak24h 38m • 3 changes
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    Arrives next day

    Valley MetroValley MetroGreyhound USAAmtrak10h 36m • 3 changes

Departing Tuesday, November 10, 2026

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    Arrives next day

    Valley MetroValley MetroGreyhound USAAmtrak24h 38m • 3 changes
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    Arrives next day

    Valley MetroValley MetroGreyhound USAAmtrak10h 36m • 3 changes

Departing Wednesday, November 11, 2026

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    Arrives next day

    Valley MetroValley MetroGreyhound USAAmtrak24h 38m • 3 changes
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    Arrives next day

    Valley MetroValley MetroGreyhound USAAmtrak10h 36m • 3 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Valley MetroValley MetroGreyhound USAAmtrak24h 38m • 3 changes
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    Arrives next day

    Valley MetroValley MetroGreyhound USAAmtrak10h 36m • 3 changes

Frequently asked questions

Want to know about travelling from Mesa to Santa Clarita? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mesa to Santa Clarita.ExpandLaunch map view
  • Distance: 433 mi
  • Duration: 16h 19m

What companies run services between Mesa, AZ, USA and Santa Clarita, CA, USA?

You can take a bus from University Dr & Mesa Dr to Santa Clarita-Newhall Amtrak Station via 24th St/Baseline PNR, 24th St & Buckeye Rd, Phoenix Bus Station, Los Angeles Union Station, and Los Angeles in around 11h 32m.

Operators