The average bus between Mestre and Roma Termini takes 7h 49m and the fastest bus takes 6h 41m. The bus service runs several times per day from Mestre to Roma Termini. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Mestre and Roma Termini. The earliest departure is at 6:50 AM in the morning, and the last departure from Mestre is at 11:50 PM which arrives into Roma Termini at 6:37 AM. All services require a transfer, and take on average 7h 49m. The schedules shown below are for the next available departures.

8h 21m • 1 change

7h 9m • 1 change

8h 55m • 1 change
Arrives next day

6h 41m • 1 change

8h 21m • 1 change

7h 9m • 1 change

8h 55m • 1 change
Arrives next day

6h 41m • 1 change

8h 21m • 1 change

7h 9m • 1 change

8h 55m • 1 change
Arrives next day

6h 41m • 1 change

8h 21m • 1 change

7h 9m • 1 change

8h 55m • 1 change
Arrives next day

6h 47m • 1 change
Want to know about travelling from Mestre to Roma Termini? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mestre to Roma Termini. However, there are services departing from Mestre station and arriving at Roma Termini station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 7h 49m.
Mestre to Roma Termini bus services, operated by FlixBus, depart from Venezia, Viale Stazione (Mestre Stazione - fermata ATVO) station.
Mestre to Roma Termini bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
The distance between Mestre and Roma Termini is 399.8 km. The road distance is 525 km.
FlixBus operates a bus from Venezia, Viale Stazione (Mestre Stazione - fermata ATVO) to Roma, Autostazione Tiburtina 4 times a day. Tickets cost €40–75 and the journey takes 6h 40m.