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Mestre to Sicily buses

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Trip Overview

The bus between Mestre and Sicily takes 22h 18m. The bus runs, on average, 6 times per week from Mestre to Sicily. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

22h 18m
Duration
1,522 km
Distance
€167
Average price
6 times a week
Frequency

Mestre to Sicily bus times

Buses run 6 times a week between Mestre and Sicily. The service departs Mestre at 1:05 PM in the afternoon, which arrives into Sicily at 11:23:00. All services require a transfer at Bologna Centrale and take an average of 22h 18m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    FlixBusFlixBusAMAT Palermo S.p.A.22h 18m • 2 changes

Departing Wednesday, November 11, 2026

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    Arrives next day

    FlixBusFlixBusAMAT Palermo S.p.A.22h 18m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    FlixBusFlixBusAMAT Palermo S.p.A.22h 18m • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    FlixBusFlixBusAMAT Palermo S.p.A.22h 18m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    FlixBusFlixBusAMAT Palermo S.p.A.22h 22m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    FlixBusFlixBusAMAT Palermo S.p.A.22h 18m • 2 changes

Frequently asked questions

Want to know about travelling from Mestre to Sicily? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mestre to Sicily.ExpandLaunch map view
  • Distance: 1,521.9 km
  • Duration: 22h 18m

What companies run services between Mestre, Italy and Sicily, Italy?

You can take a bus from Venezia, Viale Stazione (Mestre Stazione - fermata ATVO) to Piazza Boiardo via Bologna Centrale, Palermo, and Stazione Centrale Pensilina Esterna in around 21h 52m.

Operators