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Mestre to Siena buses

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Trip Overview

The average bus between Mestre and Siena takes 5h 57m and the fastest bus takes 4h 15m. The bus service runs several times per day from Mestre to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 57m
Duration
310 km
Distance
€32
Average price
4 times a day
Frequency

Bus via Florence

best
  1. Take the bus from Venezia, Viale Stazione (Mestre Stazione - fermata ATVO) to Florence Villa Constanza Bus Stationbus bus 540 / ...
  2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 1518 / ...
4h 43m
€27–41

Mestre to Siena bus times

Buses run 4 times a day between Mestre and Siena. The earliest departure is at 6:50 AM in the morning, and the last departure from Mestre is at 9:10 PM which arrives into Siena at 5:30 AM. All services require a transfer, and take on average 5h 57m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

  •  → 

    Arrives next day

    FlixBusFlixBus8h 20m • 1 change

Departing Friday, November 6, 2026

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    FlixBusFlixBus5h 5m • 1 change

  •  → 

    FlixBusFlixBus4h 15m • 1 change

  •  → 

    FlixBusFlixBus5h 50m • 1 change

  •  → 

    FlixBusFlixBus4h 45m • 1 change
  • Show more

Departing Saturday, November 7, 2026

  •  → 

    FlixBusFlixBus5h 5m • 1 change

  •  → 

    FlixBusFlixBus4h 15m • 1 change

  •  → 

    FlixBusFlixBus5h 50m • 1 change

  •  → 

    FlixBusFlixBus4h 45m • 1 change
  • Show more

Departing Sunday, November 8, 2026

  •  → 

    FlixBusFlixBus5h 5m • 1 change

  •  → 

    FlixBusFlixBus4h 15m • 1 change

  •  → 

    FlixBusFlixBus5h 50m • 1 change

  •  → 

    FlixBusFlixBus4h 45m • 1 change
  • Show more

Departing Monday, November 9, 2026

  •  → 

    FlixBusFlixBus5h 5m • 1 change

  •  → 

    FlixBusFlixBus4h 15m • 1 change

  •  → 

    FlixBusFlixBus5h 50m • 1 change

  •  → 

    FlixBusFlixBus4h 45m • 1 change
  • Show more

Departing Tuesday, November 10, 2026

  •  → 

    FlixBusFlixBus7h 30m • 1 change

  •  → 

    FlixBusFlixBus5h 50m • 1 change

  •  → 

    Arrives next day

    FlixBusFlixBus8h 20m • 1 change

Departing Wednesday, November 11, 2026

  •  → 

    FlixBusFlixBus7h 30m • 1 change

  •  → 

    FlixBusFlixBus5h 50m • 1 change

Frequently asked questions

Want to know about travelling from Mestre to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mestre to Siena.ExpandLaunch map view
  • Distance: 310.2 km
  • Duration: 5h 57m

What companies run services between Mestre, Italy and Siena, Italy?

You can take a bus from Venezia, Viale Stazione (Mestre Stazione - fermata ATVO) to Siena via Florence Villa Constanza Bus Station in around 4h 43m.

Operators