The average bus between Mestre and Vatican City takes 8h 10m and the fastest bus takes 6h 59m. The bus service runs several times per day from Mestre to Vatican City. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Mestre and Vatican City. The earliest departure is at 6:50 AM in the morning, and the last departure from Mestre is at 11:50 PM which arrives into Vatican City at 6:54 AM. All services require a transfer, and take on average 8h 10m. The schedules shown below are for the next available departures.

8h 52m • 1 change

7h 33m • 1 change

9h 11m • 1 change
Arrives next day

6h 59m • 1 change

8h 52m • 1 change

7h 33m • 1 change

9h 11m • 1 change
Arrives next day

7h 4m • 1 change

8h 46m • 1 change

7h 28m • 1 change

9h 12m • 1 change
Arrives next day

7h 4m • 1 change

8h 46m • 1 change

7h 28m • 1 change

9h 12m • 1 change
Arrives next day

7h 4m • 1 change
Want to know about travelling from Mestre to Vatican City? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mestre to Vatican City. However, there are services departing from Mestre station and arriving at Vatican City station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 8h 10m.
Mestre to Vatican City bus services, operated by FlixBus, depart from Venezia, Viale Stazione (Mestre Stazione - fermata ATVO) station.
Mestre to Vatican City bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Book your Mestre to Vatican City bus tickets online with FlixBus and ATAC S.p.A. Azienda per la mobilità.
The distance between Mestre and Vatican City is 399.3 km. The road distance is 529 km.
FlixBus operates a bus from Venezia, Viale Stazione (Mestre Stazione - fermata ATVO) to Roma, Autostazione Tiburtina 4 times a day. Tickets cost €45–75 and the journey takes 6h 40m.