The average bus between Mexico City and Santa Cruz de las Flores takes 9h 43m and the fastest bus takes 8h 47m. There is a bus service every few hours from Mexico City to Santa Cruz de las Flores. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Mexico City and Santa Cruz de las Flores. The earliest departure is at 12:30 AM at night, and the last departure from Mexico City is at 11:30 PM which arrives into Santa Cruz de las Flores at 8:44 AM. All services require a transfer at Nueva Central Camionera de Guadalajara Mod 1 and take an average of 9h 43m. The schedules shown below are for the next available departures.


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9h 27m • 2 changes
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Want to know about travelling from Mexico City to Santa Cruz de las Flores? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mexico City to Santa Cruz de las Flores. However, there are services departing from Mexico City station and arriving at Santa Cruz de las Flores station via Nueva Central Camionera de Guadalajara Mod 1. The journey, including transfers, takes approximately 9h 43m.
Mexico City to Santa Cruz de las Flores bus services, operated by Primera Plus, depart from Terminal Central de Autobuses del Norte station.
Mexico City to Santa Cruz de las Flores bus services, operated by Primera Plus, arrive at Jalisco Norte station.
The distance between Mexico City and Santa Cruz de las Flores is 472.3 km. The road distance is 564 km.
You can take a bus from Terminal Central de Autobuses del Norte to Jalisco Norte via Nueva Central Camionera de Guadalajara Mod 1, Alba, and Av. Dr. Roberto Michel in around 9h 10m.