The average bus between Mexico City and Tlayacapan takes 2h 19m and the fastest bus takes 1h 45m. There is a bus service every few hours from Mexico City to Tlayacapan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Mexico City and Tlayacapan. The earliest departure is at 7:05 AM in the morning, and the last departure from Mexico City is at 9:30 PM which arrives into Tlayacapan at 5:50 AM. All services require a transfer, and take on average 2h 19m. The schedules shown below are for the next available departures.

1h 51m • 1 change

1h 55m • 1 change

1h 55m • 1 change

2h 11m • 1 change

1h 45m • 1 change

1h 51m • 1 change

1h 51m • 1 change

1h 51m • 1 change

1h 45m • 1 change

1h 51m • 1 change

1h 51m • 1 change

1h 51m • 1 change

1h 45m • 1 change

1h 51m • 1 change

1h 51m • 1 change

1h 51m • 1 change

1h 45m • 1 change

1h 51m • 1 change

1h 51m • 1 change

1h 51m • 1 change
Want to know about travelling from Mexico City to Tlayacapan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mexico City to Tlayacapan. However, there are services departing from Mexico City station and arriving at Tlayacapan station via Oaxtepec. The journey, including transfers, takes approximately 2h 19m.
Mexico City to Tlayacapan bus services, operated by Pullman De Morelos, depart from Terminal Central Del Sur - Taxqueña station.
Mexico City to Tlayacapan bus services, operated by Pullman De Morelos, arrive at Tlayacapan station.
The distance between Mexico City and Tlayacapan is 54.5 km. The road distance is 80 km.
You can take a bus from Terminal Central Del Sur - Taxqueña to Tlayacapan via Oaxtepec in around 2h 28m.