The average bus between Mezcales and Guadalajara takes 4h 25m and the fastest bus takes 4h 21m. There is an hourly bus service from Mezcales to Guadalajara. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Mezcales and Guadalajara. The earliest departure is at 12:55 AM at night, and the last departure from Mezcales is at 5:55 PM which arrives into Guadalajara at 10:18 PM. All services require a transfer at Terminal Zapopan and take an average of 4h 25m. The schedules shown below are for the next available departures.

4h 23m • 1 change

4h 23m • 1 change

4h 23m • 1 change

4h 23m • 1 change

5h 11m • 1 change

4h 23m • 1 change

4h 23m • 1 change

4h 23m • 1 change

5h 9m • 1 change

4h 23m • 1 change

4h 26m • 1 change

4h 25m • 1 change
Want to know about travelling from Mezcales to Guadalajara? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mezcales to Guadalajara. However, there are services departing from Mezcales station and arriving at Guadalajara station via Terminal Zapopan. The journey, including transfers, takes approximately 4h 25m.
Mezcales to Guadalajara bus services, operated by Vallarta Plus, depart from Mezcales station.
Mezcales to Guadalajara bus services, operated by Vallarta Plus, arrive at Terminal Zapopan station.
The distance between Mezcales and Guadalajara is 196.8 km. The road distance is 278 km.
Vallarta Plus operates a bus from Mezcales to Terminal Zapopan hourly. Tickets cost $367–938 and the journey takes 3h 50m.