Mezcales to Guadalajara Buses

Trip Overview

The average bus between Mezcales and Guadalajara takes 4h 25m and the fastest bus takes 4h 21m. There is an hourly bus service from Mezcales to Guadalajara. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 25m
Duration: 279 km
Distance: $948
Average price: Hourly
Frequency

Bus via Terminal Zapopan

best

Take the bus from Mezcales to Terminal Zapopanbus

4h 20m

$502–995

Mezcales to Guadalajara bus times

Buses run hourly between Mezcales and Guadalajara. The earliest departure is at 12:55 AM at night, and the last departure from Mezcales is at 5:55 PM which arrives into Guadalajara at 10:18 PM. All services require a transfer at Terminal Zapopan and take an average of 4h 25m. The schedules shown below are for the next available departures.

Departing Friday, October 23, 2026

7:55 AM → 12:18 PM
4h 23m • 1 change
8:25 AM → 12:48 PM
4h 23m • 1 change
8:55 AM → 1:18 PM
4h 23m • 1 change
9:25 AM → 1:48 PM
4h 23m • 1 change
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Departing Saturday, October 24, 2026

12:55 AM → 6:06 AM
5h 11m • 1 change
1:55 AM → 6:18 AM
4h 23m • 1 change
2:55 AM → 7:18 AM
4h 23m • 1 change
4:55 AM → 9:18 AM
4h 23m • 1 change
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Departing Sunday, October 25, 2026

12:55 AM → 6:04 AM
5h 9m • 1 change
1:55 AM → 6:18 AM
4h 23m • 1 change
2:55 AM → 7:21 AM
4h 26m • 1 change
4:55 AM → 9:20 AM
4h 25m • 1 change
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Departing Monday, October 26, 2026

12:55 AM → 6:06 AM
5h 11m • 1 change
1:55 AM → 6:18 AM
4h 23m • 1 change
2:55 AM → 7:18 AM
4h 23m • 1 change
4:55 AM → 9:18 AM
4h 23m • 1 change
Show more

Departing Tuesday, October 27, 2026

12:55 AM → 6:06 AM
5h 11m • 1 change
1:55 AM → 6:18 AM
4h 23m • 1 change
2:55 AM → 7:18 AM
4h 23m • 1 change
4:55 AM → 9:18 AM
4h 23m • 1 change
Show more

Departing Wednesday, October 28, 2026

12:55 AM → 6:06 AM
5h 11m • 1 change
1:55 AM → 6:18 AM
4h 23m • 1 change
2:55 AM → 7:18 AM
4h 23m • 1 change
4:55 AM → 9:18 AM
4h 23m • 1 change
Show more

Departing Thursday, October 29, 2026

12:55 AM → 6:06 AM
5h 11m • 1 change
1:55 AM → 6:18 AM
4h 23m • 1 change
2:55 AM → 7:18 AM
4h 23m • 1 change
4:55 AM → 9:18 AM
4h 23m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Mezcales to Guadalajara? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.