The average bus between Midtown Manhattan and Penn Station takes 4h 13m and the fastest bus takes 3h 45m. There is a bus service every few hours from Midtown Manhattan to Penn Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Midtown Manhattan and Penn Station. The earliest departure is at 12:01 AM at night, and the last departure from Midtown Manhattan is at 9:00 PM which arrives into Penn Station at 1:32 AM. All services require a transfer at Baltimore and take an average of 4h 13m. The schedules shown below are for the next available departures.

4h 45m • 1 change

4h 3m • 1 change

3h 59m • 1 change

4h 3m • 1 change

4h 45m • 1 change

4h 3m • 1 change

3h 59m • 1 change

4h 3m • 1 change

4h 45m • 1 change

4h 46m • 1 change

4h 16m • 1 change

3h 46m • 1 change
Want to know about travelling from Midtown Manhattan to Penn Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Midtown Manhattan to Penn Station. However, there are services departing from Midtown Manhattan station and arriving at Penn Station station via Baltimore. The journey, including transfers, takes approximately 4h 13m.
Midtown Manhattan to Penn Station bus services, operated by Jefferson Lines, depart from New York station.
Midtown Manhattan to Penn Station bus services, operated by Jefferson Lines, arrive at Baltimore station.
The distance between Midtown Manhattan and Penn Station is 276.6 km. The road distance is 389 km.
Jefferson Lines operates a bus from New York to Baltimore hourly. Tickets cost $55–85 and the journey takes 3h 5m.