The average bus between Milan and Melendugno takes 22h 42m and the fastest bus takes 16h 30m. There is at least one bus per day from Milan to Melendugno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Milan and Melendugno. The earliest departure is at 8:15 AM in the morning, and the last departure from Milan is at 11:05 PM which arrives into Melendugno at 3:35 PM. All services require a transfer at Lecce - City Terminal and take an average of 22h 42m. The schedules shown below are for the next available departures.
Arrives next day


27h 40m • 2 changes
Arrives next day


16h 30m • 2 changes
Arrives next day


27h 40m • 2 changes
Arrives next day


16h 30m • 2 changes
Want to know about travelling from Milan to Melendugno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Milan to Melendugno. However, there are services departing from Milan station and arriving at Melendugno station via Lecce. The journey, including transfers, takes approximately 22h 42m.
Milan to Melendugno bus services, operated by FlixBus, depart from Milano, San Donato M3 station.
Milan to Melendugno bus services, operated by FlixBus, arrive at Lecce station.
The distance between Milan and Melendugno is 941.9 km. The road distance is 1,068 km.
FlixBus operates a bus from Milano, San Donato M3 to Lecce once daily. Tickets cost €85–150 and the journey takes 13h 15m.