The average bus between Milan and Mezzana takes 8h 50m and the fastest bus takes 6h 11m. The bus service runs several times per day from Milan to Mezzana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Milan and Mezzana. The earliest departure is at 8:15 AM in the morning, and the last departure from Milan is at 6:25 PM which arrives into Mezzana at 7:34 AM. All services require a transfer at Pisa and take an average of 8h 50m. The schedules shown below are for the next available departures.


6h 11m • 2 changes


6h 16m • 2 changes
Arrives next day


13h 9m • 2 changes


6h 11m • 2 changes


6h 16m • 2 changes
Arrives next day


13h 36m • 2 changes
Want to know about travelling from Milan to Mezzana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Milan to Mezzana. However, there are services departing from Milan station and arriving at Mezzana station via Pisa. The journey, including transfers, takes approximately 8h 50m.
Milan to Mezzana bus services, operated by FlixBus, depart from Milano, Autostazione Lampugnano station.
Milan to Mezzana bus services, operated by FlixBus, arrive at Pisa station.
The distance between Milan and Mezzana is 218.3 km. The road distance is 328 km.
FlixBus operates a bus from Milano, Autostazione Lampugnano to Pisa twice daily. Tickets cost €27–50 and the journey takes 5h 5m.