The average bus between Milan and Padre Pio takes 19h 2m and the fastest bus takes 13h 40m. The bus service runs several times per day from Milan to Padre Pio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Milan and Padre Pio. The earliest departure is at 8:15 AM in the morning, and the last departure from Milan is at 11:05 PM which arrives into Padre Pio at 12:45 PM. All services require a transfer at Brindisi and take an average of 19h 2m. The schedules shown below are for the next available departures.
Arrives next day

22h 55m • 1 change
Arrives next day

13h 40m • 1 change
Arrives next day

24h 45m • 1 change
Arrives next day

13h 40m • 1 change
Arrives next day

22h 55m • 1 change
Arrives next day

15h 30m • 1 change
Want to know about travelling from Milan to Padre Pio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Milan to Padre Pio. However, there are services departing from Milan station and arriving at Padre Pio station via Brindisi. The journey, including transfers, takes approximately 19h 2m.
Milan to Padre Pio bus services, operated by FlixBus, depart from Milano, San Donato M3 station.
Milan to Padre Pio bus services, operated by FlixBus, arrive at Brindisi station.
The distance between Milan and Padre Pio is 873.4 km. The road distance is 1,028 km.
FlixBus operates a bus from Milano, San Donato M3 to Brindisi once daily. Tickets cost €85–150 and the journey takes 12h 45m.