The average bus between Milan and Serrano takes 19h 36m and the fastest bus takes 14h 25m. There is at least one bus per day from Milan to Serrano. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Milan and Serrano. The earliest departure is at 8:15 AM in the morning, and the last departure from Milan is at 11:05 PM which arrives into Serrano at 1:30 PM. All services require a transfer, and take on average 19h 36m. The schedules shown below are for the next available departures.
Arrives next day

23h 45m • 1 change
Arrives next day

14h 25m • 1 change
Arrives next day

23h 45m • 1 change
Arrives next day

14h 25m • 1 change
Want to know about travelling from Milan to Serrano? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Milan to Serrano. However, there are services departing from Milan station and arriving at Serrano station via Lecce. The journey, including transfers, takes approximately 19h 36m.
Milan to Serrano bus services, operated by FlixBus, depart from Milano, San Donato M3 station.
Milan to Serrano bus services, operated by FlixBus, arrive at Lecce station.
The distance between Milan and Serrano is 949.3 km. The road distance is 1,080 km.
FlixBus operates a bus from Milano, San Donato M3 to Lecce once daily. Tickets cost €85–150 and the journey takes 13h 15m.