The average bus between Mile End (Station) and Southampton takes 4h 22m and the fastest bus takes 3h 34m. There is a bus service every few hours from Mile End (Station) to Southampton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Mile End (Station) and Southampton. The earliest departure is at 2:14 AM at night, and the last departure from Mile End (Station) is at 11:26 PM which arrives into Southampton at 3:00 AM. All services require a transfer at Victoria station and take an average of 4h 22m. The schedules shown below are for the next available departures.


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Want to know about travelling from Mile End (Station) to Southampton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mile End (Station) to Southampton. However, there are services departing from Mile End (Station) station and arriving at Southampton station via Southampton Central Station station. The journey, including transfers, takes approximately 4h 22m.
Mile End (Station) to Southampton bus services, operated by National Express, depart from London Green Line Coach Station.
Mile End (Station) to Southampton bus services, operated by National Express, arrive at Southampton Central Station.
The distance between Mile End (Station) and Southampton is 117.9 km. The road distance is 143 km.
FlixBus operates a bus from London Green Line Coach Station to Southampton Central Station 5 times a day. Tickets cost £10–17 and the journey takes 2h 45m.