The average bus between Millbrae and Santa Cruz takes 4h 20m and the fastest bus takes 3h 38m. There is an hourly bus service from Millbrae to Santa Cruz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Millbrae and Santa Cruz. The earliest departure is at 2:44 AM at night, and the last departure from Millbrae is at 8:31 PM which arrives into Santa Cruz at 12:17 AM. All services require a transfer at Palo Alto Transit Center and take an average of 4h 20m. The schedules shown below are for the next available departures.



4h 36m • 3 changes



4h 36m • 3 changes



5h • 3 changes



4h 46m • 3 changes



4h 21m • 3 changes



4h 32m • 3 changes



3h 43m • 3 changes



3h 39m • 3 changes



4h 21m • 3 changes



4h 32m • 3 changes



3h 43m • 3 changes



3h 39m • 3 changes
Want to know about travelling from Millbrae to Santa Cruz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Millbrae to Santa Cruz. However, there are services departing from Millbrae station and arriving at Santa Cruz station via Palo Alto Transit Ctr-Bay 1. The journey, including transfers, takes approximately 4h 20m.
Millbrae to Santa Cruz bus services, operated by SamTrans, depart from Millbrae Transit Center-Bay C1 station.
Millbrae to Santa Cruz bus services, operated by SamTrans, arrive at Soquel Ave & Front station.
The distance between Millbrae and Santa Cruz is 76.3 km. The road distance is 109 km.
You can take a bus from Millbrae Transit Center-Bay C1 to Soquel Ave & Front via Palo Alto Transit Center, Santa Clara & 1st, San Jose Diridon, and Diridon Station in around 4h 8m.