The average bus between Millennium Park and St. Louis takes 6h 27m and the fastest bus takes 6h 9m. The bus service runs several times per day from Millennium Park to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Millennium Park and St. Louis. The earliest departure is at 9:23 AM in the morning, and the last departure from Millennium Park is at 11:59 PM which arrives into St. Louis at 6:20 AM. All services require a transfer at Michigan & Washington and take an average of 6h 27m. The schedules shown below are for the next available departures.

6h 16m • 1 change

6h 36m • 1 change
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6h 28m • 1 change

6h 16m • 1 change

6h 36m • 1 change
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6h 28m • 1 change

6h 9m • 1 change

6h 30m • 1 change
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6h 25m • 1 change

6h 13m • 1 change

6h 29m • 1 change
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6h 20m • 1 change

6h 16m • 1 change

6h 36m • 1 change
Arrives next day

6h 28m • 1 change
Want to know about travelling from Millennium Park to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Millennium Park to St. Louis. However, there are services departing from Millennium Park station and arriving at St. Louis station via St Louis Bus Station station. The journey, including transfers, takes approximately 6h 27m.
Millennium Park to St. Louis bus services, operated by Chicago Transit (CTA), depart from Chicago Bus Station.
Millennium Park to St. Louis bus services, operated by Chicago Transit (CTA), arrive at St Louis Bus Station.
The distance between Millennium Park and St. Louis is 422.8 km. The road distance is 514 km.
Jefferson Lines operates a bus from Chicago Bus Station to St Louis Bus Station 3 times a day. Tickets cost $75–110 and the journey takes 5h 55m. Flixbus USA also services this route twice daily.