The average bus between Milpitas and San Luis Obispo takes 6h 18m and the fastest bus takes 5h 6m. The bus service runs several times per day from Milpitas to San Luis Obispo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Milpitas and San Luis Obispo. The earliest departure is at 8:07 AM in the morning, and the last departure from Milpitas is at 11:02 PM which arrives into San Luis Obispo at 9:40 AM. All services require a transfer at Berryessa / North San Jose and take an average of 6h 18m. The schedules shown below are for the next available departures.
Arrives next day


5h 58m • 2 changes
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10h 40m • 2 changes


5h 6m • 2 changes


5h 37m • 2 changes
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5h 54m • 2 changes


5h 17m • 2 changes


5h 26m • 2 changes
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5h 36m • 2 changes


5h 17m • 2 changes


5h 26m • 2 changes
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5h 36m • 2 changes


5h 17m • 2 changes


5h 26m • 2 changes
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5h 36m • 2 changes


5h 17m • 2 changes


5h 26m • 2 changes
Arrives next day


5h 36m • 2 changes
Want to know about travelling from Milpitas to San Luis Obispo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Milpitas to San Luis Obispo. However, there are services departing from Milpitas station and arriving at San Luis Obispo station via San Luis Obispo Railroad Museum. The journey, including transfers, takes approximately 6h 18m.
Milpitas to San Luis Obispo bus services, operated by Santa Clara VTA, depart from San Jose Diridon Station.
Milpitas to San Luis Obispo bus services, operated by Santa Clara VTA, arrive at San Luis Obispo Railroad Museum station.
The distance between Milpitas and San Luis Obispo is 263.4 km. The road distance is 310 km.
FlixBus-us operates a bus from San Jose Diridon Station to San Luis Obispo Railroad Museum 4 times a week, and the journey takes 3h 25m. Flixbus USA also services this route 4 times a week.