The average bus between Milpitas and South San Francisco takes 4h 1m and the fastest bus takes 2h 58m. The bus runs at least 2 times per hour from Milpitas to South San Francisco. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 30 minutes between Milpitas and South San Francisco. The earliest departure is at 5:25 AM in the morning, and the last departure from Milpitas is at 11:02 PM which arrives into South San Francisco at 5:15 AM. All services require a transfer at 2nd & Santa Clara and take an average of 4h 1m. The schedules shown below are for the next available departures.


3h 28m • 2 changes


3h 46m • 2 changes


3h 47m • 2 changes


3h 51m • 2 changes
Want to know about travelling from Milpitas to South San Francisco? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Milpitas to South San Francisco. However, there are services departing from Milpitas station and arriving at South San Francisco station via Palo Alto Transit Center. The journey, including transfers, takes approximately 4h 1m.
Milpitas to South San Francisco bus services, operated by Santa Clara VTA, depart from Santa Clara & 2nd station.
Milpitas to South San Francisco bus services, operated by Santa Clara VTA, arrive at San Bruno BART-Bay 5 station.
The distance between Milpitas and South San Francisco is 50.9 km. The road distance is 78 km.
You can take a bus from Main & Serra to San Bruno BART-Bay 5 via 2nd & Santa Clara, Santa Clara & 2nd, and Palo Alto Transit Ctr-Bay 9 in around 4h.