Rome2Rio

Milwaukee to Florence buses

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Trip Overview

The average bus between Milwaukee and Florence takes 29h 41m and the fastest bus takes 27h 30m. There is at least one bus per day from Milwaukee to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

29h 41m
Duration
1,108 mi
Distance
$234
Average price
Once daily
Frequency

Milwaukee to Florence bus times

Buses run once daily between Milwaukee and Florence. The earliest departure is at 6:45 AM in the morning, and the last departure from Milwaukee is at 9:00 AM which arrives into Florence at 1:30 PM. All services require a transfer at Chicago Bus Station and take an average of 29h 41m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA27h 30m • 2 changes

Departing Wednesday, November 11, 2026

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    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA29h 45m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA27h 30m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA27h 30m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA27h 30m • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA27h 30m • 2 changes

Frequently asked questions

Want to know about travelling from Milwaukee to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Milwaukee to Florence.ExpandLaunch map view
  • Distance: 1,107.7 mi
  • Duration: 29h 41m

What companies run services between Milwaukee, WI, USA and Florence, SC, USA?

You can take a bus from Milwaukee Intermodal Station to Florence Bus Station via Chicago Bus Station and Atlanta Bus Station in around 26h.

Operators