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Mission Viejo to Mesa buses

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Trip Overview

The average bus between Mission Viejo and Mesa takes 24h 21m and the fastest bus takes 11h 8m. The bus runs, on average, 2 times per week from Mission Viejo to Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

24h 21m
Duration
443 mi
Distance
$84
Average price
Twice a week
Frequency

Mission Viejo to Mesa bus times

Buses run twice a week between Mission Viejo and Mesa. The earliest departure is at 5:30 AM in the morning, and the last departure from Mission Viejo is at 3:30 PM which arrives into Mesa at 6:04 AM. All services require a transfer at Santa Ana-Santiago and take an average of 24h 21m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    OCTAOCTAHoang ExpressValley MetroValley Metro11h 8m • 4 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    OCTAOCTAHoang ExpressValley MetroValley Metro37h 34m • 4 changes

Frequently asked questions

Want to know about travelling from Mission Viejo to Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mission Viejo to Mesa.ExpandLaunch map view
  • Distance: 442.6 mi
  • Duration: 24h 21m

What companies run services between Mission Viejo, CA, USA and Mesa, AZ, USA?

CBX Cross Border Express operates a bus from Santa Ana to Phoenix twice daily. Tickets cost $65–95 and the journey takes 9h 30m.

Operators